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CAR T-cell Immunotherapy in Young People with Brain, Spinal Cord Tumors

The Seattle Children’s Hospital is conducting a pioneering clinical trial testing engineered immune cells as a treatment for children and young adults with a kind of brain cancer that produces the HER2 factor.

The first step in full treatment approval starts with trial testing. Those eligible for this trail are:

  • Patients 26 or younger
  • Those that have undergone surgery to remove a tumor
  • Those that have also failed first-line therapy

Those enrolled in the trial undergo an infusion of cancer-fighting chimeric antigen receptor (CAR) T-cells directly into the region of the brain where the tumor was located compared to therapies that are injected into the blood to maximize effectiveness.

CAR T-cell therapy involves collecting a patient’s own T-cells and genetically engineering them to recognize and bind to a cancer-specific protein then destroying it.

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